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Swine CCL19 (MIP-3 beta) Recombinant Protein
- Catalog Number:
- RP1223S
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Phacochoerus africanus (Common warthog), Sus scrofa (pig)
- Swine CCL19 (MIP-3β) (catalog RP1223S) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~8.8 kDa, 77 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig and common warthog. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CCL19/MIP-3β signaling and immune-cell trafficking (including migration of dendritic cells and T cells to lymphoid tissues); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | DANDAEDCCL SVTQHPIPGN LVRAFRYLLI RDGCRLPAVV FTTLKGRELC APPGQPWVER IIKRLKRKSA KSKHHRN (77) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 8.8 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Swine CCL19 (C-C motif chemokine ligand 19), also known as macrophage inflammatory protein-3β (MIP-3β) or EBI1 ligand chemokine (ELC), is a member of the CC chemokine family that plays a central role in lymphocyte trafficking and organization of secondary lymphoid tissues in pigs (Sus scrofa). CCL19 is produced primarily by stromal cells, dendritic cells, and macrophages within lymph nodes, spleen, tonsils, and other lymphoid organs, and it signals through the CCR7 receptor to direct migration of naive and central memory T cells, regulatory T cells, and mature dendritic cells. The CCL19-CCR7 axis is essential for antigen presentation, T cell priming, and maintenance of lymphoid architecture. In healthy swine, CCL19 contributes to immune surveillance and proper compartmentalization of immune cells; expression may increase during infection, vaccination, inflammatory stimulation, or immune modulation. In veterinary and translational research, swine CCL19 is particularly relevant in studies of vaccine-induced immunity and host responses to pathogens such as porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus, African swine fever virus (ASFV), and enteric pathogens. Characterization of CCL19 in pigs provides valuable insight into CCR7-mediated immune cell trafficking and adaptive immune regulation in both agricultural and biomedical research settings.
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