Swine CCL19 (C-C motif chemokine ligand 19), also known as macrophage inflammatory protein-3β (MIP-3β) or EBI1 ligand chemokine (ELC), is a member of the CC chemokine family that plays a central role in lymphocyte trafficking and organization of secondary lymphoid tissues in pigs (Sus scrofa). CCL19 is produced primarily by stromal cells, dendritic cells, and macrophages within lymph nodes, spleen, tonsils, and other lymphoid organs, and it signals through the CCR7 receptor to direct migration of naïve and central memory T cells, regulatory T cells, and mature dendritic cells. The CCL19–CCR7 axis is essential for antigen presentation, T cell priming, and maintenance of lymphoid architecture. In healthy swine, CCL19 contributes to immune surveillance and proper compartmentalization of immune cells; expression may increase during infection, vaccination, inflammatory stimulation, or immune modulation. In veterinary and translational research, swine CCL19 is particularly relevant in studies of vaccine-induced immunity and host responses to pathogens such as porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus, African swine fever virus (ASFV), and enteric pathogens. Characterization of CCL19 in pigs provides valuable insight into CCR7-mediated immune cell trafficking and adaptive immune regulation in both agricultural and biomedical research settings.