Rabbit CCL19 (MIP-3 beta) Recombinant Protein

Catalog Number:
RP1224U
Availability:
In stock
Application:
Cell Culture, Control, ELISA, ELISpot Control, Western Blot Control
100% Homology:
Oryctolagus cuniculus (rabbit)
  • Rabbit CCL19 (MIP-3β) (catalog RP1224U) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~8.6 kDa, 77 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with amino-acid homology to rabbit. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CCL19/MIP-3β signaling and immune-cell trafficking (including migration of dendritic cells and T cells to lymphoid tissues); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
Amino Acid SequenceGANDAEDCCL SVTQRPIPSN IVRAFRYLLV TDGCRVPAVV FTTLRGFQLC APPEQPWVGR IIRRLKRISA KGKYQSS (77)
EndotoxinNaturally endotoxin-free
FormLyophilized
Storage Conditions-20°C
Molecular Weight8.6 kDa
Purity>98% as visualized by SDS-PAGE analysis.
Expression SystemYeast
FormLyophilized
Country Of OriginUSA
Rabbit CCL19 (C-C motif chemokine ligand 19), also known as macrophage inflammatory protein-3β (MIP-3β) or EBI1 ligand chemokine (ELC), is a member of the CC chemokine family that plays a key role in lymphocyte trafficking and organization of secondary lymphoid tissues in rabbits (Oryctolagus cuniculus). CCL19 is produced primarily by stromal cells, dendritic cells, and macrophages within lymph nodes, spleen, and other lymphoid organs, and it signals through the CCR7 receptor to direct migration of naïve T cells, central memory T cells, regulatory T cells, and mature dendritic cells. The CCL19–CCR7 axis is essential for antigen presentation, T cell priming, and maintenance of lymphoid architecture. In healthy rabbits, CCL19 supports immune surveillance and proper immune cell compartmentalization; expression may increase during infection, vaccination, chronic inflammation, or neoplastic disease. In biomedical and translational research, rabbit CCL19 is of particular interest in studies of vaccine immunogenicity, immune-mediated disease, tumor immunology, and infectious disease models, where understanding CCR7-mediated immune cell trafficking contributes to insights into adaptive immune regulation and lymphoid tissue organization.

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