Swine EGF Recombinant Protein

Catalog Number:: RP1232S
Availability:: In stock
Application:: Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
100% Homology:: Phacochoerus africanus (Common warthog), Sus scrofa (pig)

Swine EGF (Epidermal Growth Factor) (catalog RP1232S) is a yeast-derived growth factor supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~6.1 kDa, 53 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig and common warthog. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study EGF signaling and cellular processes (including regulation of cell proliferation, differentiation, and wound healing); typical experimental uses include cell-culture stimulation and dosing studies, growth and signaling assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.

Amino Acid Sequence	NSYSECPPSH DGYCLHGGVC MYIEAVDSYA CNCVFGYVGE RCQHRDLKWW ELR (53)
Endotoxin	Naturally endotoxin-free

Storage Conditions	-20°C
Molecular Weight	6.1 kDa
Purity	>98% as visualized by SDS-PAGE analysis.
Country Of Origin	USA

Swine EGF (Epidermal Growth Factor) is a growth factor peptide belonging to the EGF family of ligands, which also includes transforming growth factor-α (TGF-α), amphiregulin (AREG), heparin-binding EGF-like growth factor (HB-EGF), betacellulin (BTC), and epiregulin (EREG) that signal through the epidermal growth factor receptor (EGFR/ErbB1) to regulate cell proliferation, differentiation, and tissue repair. In pigs (Sus scrofa), EGF is produced by epithelial cells, fibroblasts, macrophages, and glandular tissues such as salivary glands and intestinal epithelium, where it plays important roles in maintenance and regeneration of epithelial tissues, particularly in the skin and gastrointestinal tract. Binding of EGF to EGFR activates intracellular signaling pathways including MAPK/ERK, PI3K-AKT, and JAK/STAT, which promote cell proliferation, survival, and tissue remodeling following injury or inflammation. In swine physiology, EGF contributes to intestinal epithelial growth and repair, supporting gut barrier integrity and nutrient absorption. Because pigs share strong anatomical and physiological similarities with humans, they are widely used as translational animal models for gastrointestinal and regenerative medicine research, and EGF signaling has been studied in porcine models of intestinal injury and wound healing to investigate epithelial regeneration and therapeutic approaches for human gastrointestinal diseases.

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