Swine EGF (Epidermal Growth Factor) is a growth factor peptide belonging to the EGF family of ligands, which also includes transforming growth factor-α (TGF-α), amphiregulin (AREG), heparin-binding EGF-like growth factor (HB-EGF), betacellulin (BTC), and epiregulin (EREG) that signal through the epidermal growth factor receptor (EGFR/ErbB1) to regulate cell proliferation, differentiation, and tissue repair. In pigs (Sus scrofa), EGF is produced by epithelial cells, fibroblasts, macrophages, and glandular tissues such as salivary glands and intestinal epithelium, where it plays important roles in maintenance and regeneration of epithelial tissues, particularly in the skin and gastrointestinal tract. Binding of EGF to EGFR activates intracellular signaling pathways including MAPK/ERK, PI3K–AKT, and JAK/STAT, which promote cell proliferation, survival, and tissue remodeling following injury or inflammation. In swine physiology, EGF contributes to intestinal epithelial growth and repair, supporting gut barrier integrity and nutrient absorption. Because pigs share strong anatomical and physiological similarities with humans, they are widely used as translational animal models for gastrointestinal and regenerative medicine research, and EGF signaling has been studied in porcine models of intestinal injury and wound healing to investigate epithelial regeneration and therapeutic approaches for human gastrointestinal diseases.