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Canine CCL19 (MIP-3 beta) Recombinant Protein
- Catalog Number:
- RP1254D
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Canis lupus dingo (dingo), Canis lupus familiaris (dog), Vulpes lagopus (Arctic fox)
- Canine CCL19 (MIP-3β) (catalog RP1254D) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~8.6 kDa, 77 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to dog, dingo, and Arctic fox. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CCL19/MIP-3β signaling and immune-cell trafficking (including migration of dendritic cells and T cells to lymphoid tissues); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | GANDAEDCCL SVTQRPIPGN IVRAFHYLLI KDGCRLPAVV FTTLKGRQLC APPDQPWVDR IIRRLQKNSA KNKGHSS (77) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 8.6 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Canine CCL19 (C-C motif chemokine ligand 19), also known as macrophage inflammatory protein-3β (MIP-3β) or EBI1 ligand chemokine (ELC), is a member of the CC chemokine family that plays a central role in lymphocyte trafficking and organization of secondary lymphoid tissues in dogs (Canis lupus familiaris). CCL19 is produced primarily by stromal cells, dendritic cells, and macrophages within lymph nodes, spleen, and other lymphoid structures. It functions through the CCR7 receptor to direct migration of naive T cells, central memory T cells, and mature dendritic cells to lymphoid tissues, facilitating antigen presentation and initiation of adaptive immune responses. In healthy dogs, CCL19 supports immune surveillance and maintenance of lymphoid architecture; however, expression may increase during infection, vaccination, chronic inflammation, or neoplastic disease. In veterinary and comparative medicine research, canine CCL19 is of particular interest in studies of vaccine responses, immune-mediated diseases, lymphoma and other lymphoid malignancies, and infectious diseases such as canine distemper virus and leishmaniasis. Characterization of CCL19 in dogs provides valuable insight into CCR7-mediated immune cell trafficking, lymphoid tissue organization, and adaptive immune regulation in both veterinary and translational research contexts.
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