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Equine IFN lambda 3 (IL-28B) Recombinant Protein
- Catalog Number:
- RP1279E
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Equus caballus (horse)
- Equine IL-28B (Interleukin-28B, IFN-λ3) (catalog RP1279E) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~19.0 kDa, 170 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to horse. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-28B/IFN-λ3 signaling and antiviral immune responses (including induction of interferon-stimulated genes and innate immune activation); typical experimental uses include cell-culture stimulation and dosing studies, cytokine signaling assays, antiviral assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | GPVPTSKPAT TQRSCDIGRF KSLSPSELEA FKKAKDALEN SLENWTCRSP VFPTTWDLRQ LQVWERPVAL EAELALTLKI LAMVADSSLA DILDRPLHTL RHIHSELQAC VPARPTAGPG PRGRLHQWLR QLHEVQKKES WGCLEASVTF NLFRLLTRDL NCVASGDLCL (170) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 19.0 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Equine interferon lambda 3 (IFN-λ3), also known as interleukin-28B (IL-28B), is a member of the type III interferon family (IFN-λ1/IL-29, IFN-λ2/IL-28A, IFN-λ3/IL-28B, and IFN-λ4) and functions as a key antiviral cytokine that signals through the IFNLR1 (IL-28Rα)/IL-10R2 receptor complex, activating JAK/STAT pathways and inducing interferon-stimulated genes (ISGs) that inhibit viral replication primarily at epithelial surfaces. In horses, IFN-λ3 is particularly important in mucosal immunity within the respiratory tract, a primary site of infection for pathogens such as equine influenza virus (EIV), equine herpesvirus (EHV-1 and EHV-4), and equine rhinitis viruses. Because type III interferons generate localized antiviral protection with reduced systemic inflammation compared to type I interferons, equine IFN-λ3 likely plays a critical role in controlling viral replication while limiting tissue damage that can impair performance and recovery. As respiratory disease significantly impacts equine health and the racing and sport industries, equine IFN-λ3 (IL-28B) is highly relevant for understanding host antiviral defense, improving vaccine design, and developing immunomodulatory strategies to enhance disease resistance and biosecurity in equine populations.
5 ug
Price: $170.00
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