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Human Oncostatin M (OSM) Recombinant Protein
- Catalog Number:
- RP1283H
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Homo sapiens (human)
- Human Oncostatin M (OSM) (catalog RP1283H) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~22.2 kDa, 196 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to human. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study OSM signaling and cellular responses (including regulation of inflammation, cell proliferation, and differentiation); typical experimental uses include cell-culture stimulation and dosing studies, cytokine signaling assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | AAIGSCSKEY RVLLGQLQKQ TDLMQDTSRL LDPYIRIQGL DVPKLREHCR ERPGAFPSEE TLRGLGRRGF LQTLNATLGC VLHRLADLEQ RLPKAQDLER SGLNIEDLEK LQMARPNILG LRNNIYCMAQ LLDNSDTAEP TKAGRGASQP PTPTPASDAF QRKLEGCRFL HGYHRFMHSV GRVFSKWGES PNRSRR (196) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 22.2 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Human Oncostatin M (OSM) is a multifunctional cytokine belonging to the IL-6 cytokine family, which also includes IL-6, IL-11, leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), ciliary neurotrophic factor (CNTF), cardiotrophin-like cytokine factor 1 (CLCF1), and IL-27. OSM signals through receptor complexes containing the shared gp130 (IL6ST) subunit together with either the oncostatin M receptor (OSMR) or leukemia inhibitory factor receptor (LIFR), leading to activation of intracellular signaling pathways such as JAK/STAT (particularly STAT3), MAPK, and PI3K/AKT. Human OSM is produced mainly by activated T lymphocytes, monocytes/macrophages, neutrophils, and dendritic cells and plays important roles in regulating inflammation, hematopoiesis, immune responses, and tissue remodeling. OSM influences the behavior of endothelial cells, fibroblasts, epithelial cells, and hepatocytes, promoting cytokine production, acute-phase responses, and extracellular matrix remodeling. Dysregulated OSM signaling has been implicated in several chronic inflammatory and autoimmune diseases, including rheumatoid arthritis, inflammatory bowel disease, psoriasis, and pulmonary or liver fibrosis, where it contributes to persistent inflammatory signaling and tissue damage. OSM is also involved in cancer biology, influencing tumor cell proliferation, angiogenesis, and tumor microenvironment remodeling in cancers such as breast, colorectal, and pancreatic cancer. Because of its central role in inflammation and tissue remodeling, human OSM is widely studied as both a biomarker and therapeutic target in inflammatory disease, fibrosis, and oncology.
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