Rabbit CCL11 (C-C motif chemokine ligand 11), also known as eotaxin-1, is a member of the CC chemokine family that regulates eosinophil recruitment and type 2–associated immune responses in rabbits (Oryctolagus cuniculus). CCL11 is produced primarily by epithelial cells, fibroblasts, endothelial cells, smooth muscle cells, and activated immune cells in response to Th2-associated cytokines such as IL-4 and IL-13, as well as inflammatory stimuli. It functions predominantly through the CCR3 receptor to promote chemotaxis and activation of eosinophils, and can also influence basophils and certain Th2 lymphocytes. In healthy rabbits, basal CCL11 expression is typically low, but levels increase during allergic airway inflammation, parasitic infection, immune complex–mediated disease, and experimental immune stimulation. In biomedical research, rabbit CCL11 is particularly relevant in models of asthma, allergic rhinitis, eosinophilic inflammation, and helminth infection, where rabbits are used to study airway hyperresponsiveness and Th2-driven pathology. Characterization of CCL11 in rabbits provides valuable insight into eosinophil biology, chemokine-mediated leukocyte trafficking, and mechanisms underlying allergic and type 2–mediated inflammatory responses in translational research settings.