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Bovine FGF basic Recombinant Protein
- Catalog Number:
- RP1304B
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Bos taurus (cattle)
- Bovine FGF basic (Fibroblast Growth Factor 2, FGF-2) (catalog RP1304B) is a yeast-derived growth factor supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~16.3 kDa, 145 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to cattle. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study FGF signaling and cellular processes (including regulation of cell proliferation, differentiation, angiogenesis, and tissue repair); typical experimental uses include cell-culture stimulation and growth assays, signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | SLPEDGGSGA FPPGHFKDPK RLYCKNGGFF LRIHPDGRVD GVREKSDPHI KLQLQAEERG VVSIKGVCAN RYLAMKEDGR LLASKCVTDE CFFFERLESN NYNTYRSRKY SSWYVALKRT GQYKLGPKTG PGQKAILFLP MSAKS (145) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 16.3 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Bovine Basic Fibroblast Growth Factor (FGF2, also known as bFGF) is a heparin-binding growth factor belonging to the fibroblast growth factor (FGF) family, which includes more than 20 related proteins involved in cell proliferation, differentiation, angiogenesis, and tissue repair. In cattle (Bos taurus), FGF2 is produced by fibroblasts, endothelial cells, macrophages, and other stromal and epithelial cells, where it plays important roles in wound healing, vascular development, and tissue regeneration. Bovine FGF2 signals through fibroblast growth factor receptors (FGFR1-FGFR4) in the presence of heparan sulfate proteoglycans, activating intracellular pathways such as MAPK/ERK, PI3K-AKT, and PLCγ, which promote cell proliferation, migration, and angiogenesis. In bovine physiology, FGF2 contributes to development and repair of connective tissues, blood vessels, and muscle, and it is also involved in reproductive biology, including follicular development and ovarian function. Because of its strong ability to stimulate cell growth and angiogenesis, bovine FGF2 has been widely used in cell culture systems and stem cell research as a growth supplement to support proliferation and maintenance of mammalian cells, making it an important molecule in biotechnology, regenerative medicine, and veterinary research.
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