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Bovine PDGF-BB Recombinant Protein
- Catalog Number:
- RP1319B
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Bison bison bison (American Buffalo), Bos mutus (wild yak), Bos taurus (cattle)
- Bovine PDGF-BB (Platelet-Derived Growth Factor-BB) (catalog RP1319B) is a yeast-derived growth factor supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~12.3 kDa (monomer), 109 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to cattle, American buffalo, and wild yak. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study PDGF signaling and cellular processes (including regulation of cell proliferation, migration, and wound healing); typical experimental uses include cell-culture stimulation and proliferation assays, signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | SLGSPTVAAE PAVIAECKTR TEVFEISRRL IDRTNANFLV WPPCVEVQRC SGCCNNRNVQ CRPTQVQDRK VQVKKIEIVR KKKIFKKATV TLVDHLACRC ETVVARAVT (109) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 12.3 kDa (monomer) |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Bovine Platelet-Derived Growth Factor-BB (PDGF-BB) is a homodimeric growth factor composed of two PDGF-B chains that plays a key role in cell proliferation, migration, angiogenesis, and tissue repair in cattle (Bos taurus). PDGF-BB signals primarily through platelet-derived growth factor receptor-β (PDGFR-β) and PDGFR-α/β receptor complexes, activating intracellular pathways including PI3K/AKT, MAPK, and STAT, which regulate fibroblast proliferation, smooth muscle cell growth, and extracellular matrix production. In cattle, PDGF-BB is produced by platelets, macrophages, endothelial cells, and fibroblasts and is released during tissue injury, inflammation, and wound healing. It plays important roles in connective tissue repair, vascular remodeling, and dermal regeneration, particularly following injury or infection. PDGF-BB signaling is also relevant in bovine health conditions such as mastitis and inflammatory tissue damage, where it contributes to tissue repair and remodeling of mammary gland structures. Additionally, PDGF-BB participates in fibrotic responses and stromal cell activation during chronic inflammation. As a regulator of cell growth, angiogenesis, and tissue regeneration, bovine PDGF-BB is important for studies of wound healing, mammary gland biology, fibrosis, and regenerative processes relevant to cattle health and livestock productivity.
5 ug
Price: $170.00
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