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Canine PDGF-BB Recombinant Protein
- Catalog Number:
- RP1322D
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Canis lupus dingo (dingo), Canis lupus familiaris (dog), Vulpes vulpes (red fox)
- Canine PDGF-BB (Platelet-Derived Growth Factor-BB) (catalog RP1322D) is a yeast-derived growth factor supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~12.3 kDa (monomer), 109 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to dog, dingo, and red fox. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study PDGF signaling and cellular processes (including regulation of cell proliferation, migration, and wound healing); typical experimental uses include cell-culture stimulation and proliferation assays, signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | SLGSPTVAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV QVRKIEIVRK KPTFKKATVT LEDHLACKCE TVVAARPVT (109) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 12.3 kDa (monomer) |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Canine Platelet-Derived Growth Factor-BB (PDGF-BB) is a homodimeric growth factor composed of two PDGF-B chains that plays a central role in cell proliferation, migration, angiogenesis, and tissue repair in dogs (Canis lupus familiaris). PDGF-BB signals primarily through platelet-derived growth factor receptor-β (PDGFR-β) and PDGFR-α/β receptor complexes, activating intracellular signaling pathways including PI3K/AKT, MAPK, and STAT, which regulate fibroblast activation, smooth muscle cell proliferation, and extracellular matrix production. In dogs, PDGF-BB is produced by platelets, macrophages, endothelial cells, fibroblasts, and other stromal cells, and is released during tissue injury, inflammation, and wound healing. It plays important roles in dermal repair, vascular remodeling, and connective tissue regeneration, contributing to healing of skin wounds, surgical sites, and musculoskeletal injuries. PDGF-BB signaling is also implicated in fibrotic processes and tumor biology, including canine fibrosarcoma, osteosarcoma, and mast cell tumors, where PDGF-driven signaling can promote tumor cell proliferation and tumor microenvironment remodeling. Because of its involvement in angiogenesis, tissue regeneration, and cellular growth signaling, canine PDGF-BB is widely studied in research on wound healing, regenerative medicine, fibrosis, and cancer biology, with relevance to both veterinary treatment strategies and comparative oncology.
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