Rabbit Basic Fibroblast Growth Factor (FGF2, also known as bFGF) is a heparin-binding growth factor belonging to the fibroblast growth factor (FGF) family, which includes more than 20 related proteins involved in cell proliferation, differentiation, angiogenesis, and tissue repair. In rabbits (Oryctolagus cuniculus), FGF2 is produced by fibroblasts, endothelial cells, macrophages, and other stromal and epithelial cells, where it plays important roles in wound healing, vascular development, and tissue regeneration. FGF2 binds to fibroblast growth factor receptors (FGFR1–FGFR4) in the presence of heparan sulfate proteoglycans, activating intracellular signaling pathways such as MAPK/ERK, PI3K–AKT, and PLCγ, which promote cell proliferation, migration, survival, and angiogenesis. In rabbit physiology, FGF2 contributes to repair of connective tissues, skin regeneration, and formation of new blood vessels during healing processes. Rabbits are widely used as animal models for wound healing and angiogenesis research, and FGF2 has been studied in rabbit models of corneal injury and tissue repair, where FGF2-mediated signaling promotes corneal epithelial regeneration and neovascularization, providing insights into growth factor–driven tissue repair and regenerative therapies relevant to human medicine.