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Swine Oncostatin M (OSM) Recombinant Protein
- Catalog Number:
- RP1329S
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Sus scrofa (pig)
- Swine Oncostatin M (OSM) (catalog RP1329S) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~20.4 kDa, 181 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study OSM signaling and cellular responses (including regulation of inflammation, cell proliferation, and differentiation); typical experimental uses include cell-culture stimulation and dosing studies, cytokine signaling assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | GKCSGKYHEL LRQLRHQADH MRDTSTLLDP YIRMQGLDTP GLKEHCKDRP GAFPSESTLR GFSKRVFLQT LNTTLGLVLH RLTALQQDLP EAQHLARLNI RGLRSNIHCM SQLLLGSSEA ETAEPTQPGP RATPPPTPPS DAFQHKLKGC RFLHGYHSFM HSVAQVLREW GESPGRSRSR R (181) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 20.4 kda |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Swine Oncostatin M (OSM) is a multifunctional cytokine belonging to the IL-6 cytokine family, which also includes IL-6, IL-11, leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), ciliary neurotrophic factor (CNTF), cardiotrophin-like cytokine factor 1 (CLCF1), and IL-27. In pigs (Sus scrofa domesticus), OSM signals through receptor complexes containing the shared gp130 (IL6ST) subunit together with the oncostatin M receptor (OSMR), activating intracellular signaling pathways including JAK/STAT (particularly STAT3), MAPK, and PI3K/AKT. Swine OSM is produced primarily by activated T lymphocytes, macrophages, neutrophils, and dendritic cells and functions in regulation of inflammation, immune responses, hematopoiesis, and tissue remodeling. In swine health, OSM-mediated signaling is relevant during respiratory and systemic infections, including diseases such as porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza, where cytokine-driven inflammatory responses influence leukocyte activation and tissue repair in affected organs. OSM may also contribute to fibrotic responses and epithelial or stromal cell regulation during chronic inflammation. Because pigs are widely used as large-animal models for human inflammatory and metabolic diseases, characterization of swine OSM supports research into IL-6 family cytokine signaling, host-pathogen interactions, inflammatory disease mechanisms, and tissue remodeling, with applications in both veterinary medicine and translational biomedical research.
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