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Equine SCF (Stem Cell Factor) Recombinant Protein
- Catalog Number:
- RP1334E
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Equus asinus (ass), Equus caballus (horse)
- Equine SCF (Stem Cell Factor, KIT Ligand, KITLG) (catalog RP1334E) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~18.8 kDa, 165 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to horse and ass. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study SCF/KIT signaling and hematopoiesis (including regulation of stem cell maintenance, proliferation, and differentiation); typical experimental uses include cell-culture stimulation and differentiation assays, cytokine signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | KGICENRVTD DVKDVTKLVA NLPKDYKITL KYVPGMDVLP SHCWISEMVQ HLSVSLTDLL EKFSNISEGL SNYSIIDKLV KIVDDLVECM EEHSSENVKK SYKSQESRLF TPEEFFRIFN RSIDAFKDLE MVVSKTSECV VSSTLSPEKD SRVSVTKPFM LPPVAA (166) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 18.8 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Equine Stem Cell Factor (SCF) (also known as KIT ligand, KITLG, mast cell growth factor, or steel factor) is a cytokine and growth factor that plays an important role in hematopoiesis, stem cell maintenance, and immune cell development in horses (Equus caballus). SCF belongs to a group of hematopoietic growth factors that regulate the survival, proliferation, and differentiation of stem and progenitor cells. It functions by binding to the c-Kit receptor (CD117), a receptor tyrosine kinase expressed on hematopoietic stem cells, mast cells, melanocytes, and germ cells, activating intracellular signaling pathways such as PI3K/AKT, MAPK, and JAK/STAT that regulate cell survival, proliferation, and differentiation. In horses, SCF is produced by stromal cells, fibroblasts, endothelial cells, and epithelial cells, and exists in both membrane-bound and soluble forms, allowing both localized and systemic regulation of c-Kit-expressing cells. Equine SCF contributes to bone marrow hematopoiesis, mast cell development, pigmentation, and reproductive cell biology, and plays a role in maintaining the hematopoietic stem cell niche. Because horses are increasingly studied in regenerative medicine and stem cell-based therapies, characterization of equine SCF supports research on hematopoietic stem cell regulation, tissue regeneration, and immune cell development, with relevance to equine health, wound healing, and musculoskeletal repair.
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