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Feline PDGF-BB Recombinant Protein
- Catalog Number:
- RP1380F
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Acinonyx jubatus (cheetah), Felis catus (domestic cat), Leopardus geoffroyi (Geoffroy's cat), Lynx pardinus (Spanish lynx), Lynx rufus (bobcat), Panthera leo (lion), Panthera pardus (leopard), Panthera tigris (tiger), Panthera tigris altaica (Amur tiger), Panthera uncia (snow leopard), Puma yagouaroundi (jaguarundi)
- Feline PDGF-BB (Platelet-Derived Growth Factor-BB) (catalog RP1380F) is a yeast-derived growth factor supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~12.3 kDa (monomer), 105 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to domestic cat, cheetah, Geoffroy's cat, Spanish lynx, bobcat, lion, leopard, tiger, Amur tiger, snow leopard, and jaguarundi. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study PDGF signaling and cellular processes (including regulation of cell proliferation, migration, and wound healing); typical experimental uses include cell-culture stimulation and proliferation assays, signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | EAAGSPTVAE PAMIAECKTR TEVFEVSRRL IDRTNANFLV WPPCVEVQRC SGCCNNRNVQ CRPTQVQLRL VQVRKIEIVR KRPVFKKATV TLEDHLACKC ETVVA (105) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 11.9 kDa (monomer) |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Feline Platelet-Derived Growth Factor-BB (PDGF-BB) is a homodimeric growth factor composed of two PDGF-B chains that plays a key role in cell proliferation, migration, angiogenesis, and tissue repair in cats (Felis catus). PDGF-BB signals primarily through the PDGF receptor-β (PDGFR-β) and PDGFR-α/β receptor complexes, activating downstream signaling pathways including PI3K/AKT, MAPK, and STAT, which regulate fibroblast activation, smooth muscle cell proliferation, and extracellular matrix production. In cats, PDGF-BB is produced by platelets, macrophages, endothelial cells, and fibroblasts, and is released during tissue injury, inflammation, and wound healing. It plays important roles in dermal repair, vascular remodeling, and connective tissue regeneration, supporting healing of skin wounds and surgical sites. PDGF-BB signaling is also implicated in fibrotic processes and tumor biology, including feline fibrosarcoma and other mesenchymal tumors, where PDGF-driven cell proliferation and stromal interactions can influence tumor growth and tissue remodeling. Because of its central role in regulating cell growth, angiogenesis, and tissue regeneration, feline PDGF-BB is studied in research on wound healing, fibrosis, cancer biology, and regenerative medicine, contributing to improved understanding of tissue repair mechanisms and disease processes in cats.
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