Feline EGF (Epidermal Growth Factor) is a growth factor peptide belonging to the EGF family of ligands, which also includes transforming growth factor-α (TGF-α), amphiregulin (AREG), heparin-binding EGF-like growth factor (HB-EGF), betacellulin (BTC), and epiregulin (EREG) that signal through the epidermal growth factor receptor (EGFR/ErbB1) to regulate cell proliferation, differentiation, and tissue repair. In cats (Felis catus), EGF is produced by epithelial cells, fibroblasts, macrophages, and glandular tissues such as salivary glands, and it plays an important role in epithelial maintenance, wound healing, and regeneration of skin and mucosal tissues. Upon binding to EGFR, feline EGF activates intracellular signaling pathways including MAPK/ERK, PI3K–AKT, and JAK/STAT, which promote cell survival, proliferation, and tissue remodeling following injury or inflammation. In feline health, EGF contributes to repair of epithelial barriers and regulation of cellular growth, particularly in tissues such as the skin, gastrointestinal tract, and cornea. Cats also serve as valuable animal models for comparative dermatology and regenerative medicine, and studies of EGF signaling in feline wound healing and skin repair have helped researchers better understand EGFR-mediated tissue regeneration and epithelial repair mechanisms relevant to both veterinary and human medicine.