Feline EGF Recombinant Protein

Catalog Number:: RP1408F
Availability:: In stock
Application:: Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
100% Homology:: Acinonyx jubatus (cheetah), Felis catus (domestic cat), Lynx canadensis (Canada lynx), Lynx pardinus (Spanish lynx), Panthera leo (lion), Panthera pardus (leopard), Panthera tigris (tiger), Panthera uncia (snow leopard), Prionailurus viverrinus (fishing cat), Puma concolor (puma)

Feline EGF (Epidermal Growth Factor) (catalog RP1408F) is a yeast-derived growth factor supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~6.2 kDa, 52 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to domestic cat, cheetah, Canada lynx, Spanish lynx, lion, leopard, tiger, snow leopard, fishing cat, and puma. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study EGF signaling and cellular processes (including regulation of cell proliferation, differentiation, and survival); typical experimental uses include cell-culture stimulation and growth assays, signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.

Amino Acid Sequence	NSYQECPPSY DGYCLYNGVC MYIEAVDRYA CNCVFGYVGE RCQHRDLKWE LR (52)
Endotoxin	Naturally endotoxin-free

Storage Conditions	-20°C
Molecular Weight	6.2 kDa
Purity	>98% as visualized by SDS-PAGE analysis.
Country Of Origin	USA

Feline EGF (Epidermal Growth Factor) is a growth factor peptide belonging to the EGF family of ligands, which also includes transforming growth factor-α (TGF-α), amphiregulin (AREG), heparin-binding EGF-like growth factor (HB-EGF), betacellulin (BTC), and epiregulin (EREG) that signal through the epidermal growth factor receptor (EGFR/ErbB1) to regulate cell proliferation, differentiation, and tissue repair. In cats (Felis catus), EGF is produced by epithelial cells, fibroblasts, macrophages, and glandular tissues such as salivary glands, and it plays an important role in epithelial maintenance, wound healing, and regeneration of skin and mucosal tissues. Upon binding to EGFR, feline EGF activates intracellular signaling pathways including MAPK/ERK, PI3K-AKT, and JAK/STAT, which promote cell survival, proliferation, and tissue remodeling following injury or inflammation. In feline health, EGF contributes to repair of epithelial barriers and regulation of cellular growth, particularly in tissues such as the skin, gastrointestinal tract, and cornea. Cats also serve as valuable animal models for comparative dermatology and regenerative medicine, and studies of EGF signaling in feline wound healing and skin repair have helped researchers better understand EGFR-mediated tissue regeneration and epithelial repair mechanisms relevant to both veterinary and human medicine.

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