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Chicken EGF Recombinant Protein
- Catalog Number:
- RP1409C
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Gallus gallus (chicken)
- Chicken EGF (Epidermal Growth Factor) (catalog RP1409C) is a yeast-derived growth factor supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~6.2 kDa, 55 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to chicken. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study EGF signaling and cellular processes (including regulation of cell proliferation, differentiation, and survival); typical experimental uses include cell-culture stimulation and growth assays, signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | GDSIGCPPAY DSYCLHGGVC NYVSDLQDYA CNCVTGYVGE RCQFSDLEWW EQQHA (55) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 6.2 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Chicken EGF (Epidermal Growth Factor) is a growth factor peptide belonging to the EGF family of ligands, which also includes transforming growth factor-α (TGF-α), amphiregulin (AREG), heparin-binding EGF-like growth factor (HB-EGF), betacellulin (BTC), and epiregulin (EREG) that signal through the epidermal growth factor receptor (EGFR/ErbB1) to regulate cell proliferation, differentiation, and tissue repair. In chickens (Gallus gallus), EGF is produced by epithelial cells, fibroblasts, macrophages, and glandular tissues, particularly within the gastrointestinal tract and developing embryonic tissues, where it plays an important role in epithelial development, intestinal growth, and tissue regeneration. Binding of EGF to EGFR activates intracellular signaling pathways such as MAPK/ERK and PI3K-AKT, which promote cell proliferation, survival, and differentiation of epithelial cells. In poultry biology, EGF contributes to maintenance and repair of intestinal epithelium, supporting nutrient absorption and barrier integrity in the digestive tract. Because chickens are widely used as animal models for developmental biology and embryology, chicken EGF has been studied in avian embryo and limb development models, where EGF signaling helps regulate cell proliferation and tissue patterning during embryonic growth, providing insights into growth factor signaling and tissue development across vertebrate species.
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