Rabbit Interleukin-16 (IL-16) is a proinflammatory cytokine that plays an important role in regulating immune cell recruitment and activation in rabbits (Oryctolagus cuniculus). IL-16 is produced by several cell types, including CD8⁺ T cells, mast cells, eosinophils, and epithelial cells, in response to immune stimulation or inflammatory signals. Rabbit IL-16 functions primarily as a chemoattractant for CD4⁺ immune cells by binding to the CD4 receptor, promoting migration and activation of T helper cells, monocytes, and dendritic cells to sites of infection or inflammation. Through these actions, IL-16 contributes to coordination of immune responses and modulation of inflammatory signaling pathways. In rabbits, IL-16 participates in immune responses against bacterial, viral, and parasitic infections and may influence inflammatory processes in tissues such as the respiratory and gastrointestinal tracts. In cell culture, recombinant rabbit IL-16 is commonly used to study chemotaxis and activation of CD4⁺ immune cells, investigate mechanisms of immune cell recruitment, and evaluate cytokine-mediated regulation of inflammatory pathways. Rabbit IL-16 is also studied in rabbit models of infectious and inflammatory diseases, where it helps researchers examine immune cell trafficking and immune regulation relevant to both veterinary and translational biomedical research.