Rabbit angiogenin (ANG) is a secreted ribonuclease belonging to the RNase A superfamily that plays a key role in angiogenesis, tissue remodeling, and cellular stress responses. In rabbits (Oryctolagus cuniculus), angiogenin is produced by endothelial cells, epithelial cells, macrophages, and various stromal cell types, where it promotes endothelial cell proliferation, migration, and capillary tube formation through activation of pro-angiogenic signaling pathways and regulation of ribosomal RNA transcription. In addition to its vascular effects, rabbit angiogenin contributes to cellular survival under stress conditions and may participate in innate immune and inflammatory responses. Baseline circulating levels in healthy rabbits are generally low, but expression can increase during wound healing, ischemia, inflammatory conditions, tumor growth, and experimental vascular injury models. In biomedical and translational research, rabbit angiogenin is particularly relevant in models of atherosclerosis, corneal neovascularization, wound repair, tumor angiogenesis, and cardiovascular disease, where rabbits are commonly used due to their suitability for vascular and lipid metabolism studies. Characterizing angiogenin expression in rabbits provides valuable insight into mechanisms of neovascularization, tissue regeneration, and angiogenesis-driven disease processes in experimental research settings.