Swine angiogenin (ANG) is a secreted ribonuclease belonging to the RNase A superfamily that plays a critical role in angiogenesis, tissue remodeling, and cellular stress responses. In pigs (Sus scrofa), angiogenin is produced by endothelial cells, epithelial cells, macrophages, and various stromal cell types, where it promotes endothelial cell proliferation, migration, and capillary formation through activation of pro-angiogenic signaling pathways and stimulation of ribosomal RNA transcription. Beyond its vascular effects, swine angiogenin is involved in cellular survival under hypoxic or inflammatory stress and may contribute to regulation of innate immune responses and tissue repair processes. In healthy pigs, circulating angiogenin levels are typically low to moderate, but expression may increase during wound healing, ischemia, inflammation, tumor development, and experimental models of cardiovascular or metabolic disease. In veterinary and translational research, swine angiogenin is of particular interest in models of myocardial infarction, peripheral vascular disease, wound healing, surgical repair, and oncology, given the physiological and cardiovascular similarities between pigs and humans. Characterizing angiogenin expression in swine provides valuable insight into mechanisms of neovascularization, regenerative biology, and angiogenesis-driven pathology in both agricultural and biomedical research contexts.