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Rat PDGF-BB Recombinant Protein
- Catalog Number:
- RP1447R
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Acomys russatus (golden spiny mouse), Rattus norvegicus (Norway rat)
- Rat PDGF-BB (Platelet-Derived Growth Factor-BB) (catalog RP1447R) is a yeast-derived growth factor supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~12.2 kDa (monomer), 109 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to Norway rat and golden spiny mouse. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study PDGF signaling and cellular processes (including regulation of cell proliferation, migration, and wound healing); typical experimental uses include cell-culture stimulation and proliferation assays, signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | SLGSLAAAEP AVIAECKTRT EVFQISRNLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RASQVQMRPV QVRKIEIVRK KPVFKKATVT LEDHLACKCE TVVTPRPVT (109) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 12.2 kDa (monomer) |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Rat Platelet-Derived Growth Factor-BB (PDGF-BB) is a homodimeric growth factor composed of two PDGF-B chains that regulates cell proliferation, migration, angiogenesis, and tissue repair in rats (Rattus norvegicus). PDGF-BB signals primarily through platelet-derived growth factor receptor-β (PDGFR-β) and PDGFR-α/β receptor complexes, activating downstream signaling pathways including PI3K/AKT, MAPK, and STAT, which control fibroblast activation, smooth muscle cell proliferation, and extracellular matrix production. In rats, PDGF-BB is produced by platelets, macrophages, endothelial cells, fibroblasts, and other stromal cells, and is released during tissue injury, inflammation, and wound healing. Rat PDGF-BB is extensively studied in experimental models of cardiovascular disease, fibrosis, wound healing, and cancer, where PDGF signaling contributes to vascular smooth muscle cell proliferation, angiogenesis, and tissue remodeling. It plays key roles in rat models of atherosclerosis, kidney fibrosis, liver injury, and vascular restenosis, where PDGF-driven signaling influences inflammatory responses and extracellular matrix deposition. Because rats are widely used in pharmacology, toxicology, and cardiovascular research, characterization of rat PDGF-BB supports investigations into growth factor signaling, vascular remodeling, and regenerative processes relevant to human disease and therapeutic development.
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