Rabbit Platelet-Derived Growth Factor-BB (PDGF-BB) is a homodimeric growth factor composed of two PDGF-B chains that plays a key role in cell proliferation, migration, angiogenesis, and tissue repair in rabbits (Oryctolagus cuniculus). PDGF-BB signals primarily through platelet-derived growth factor receptor-β (PDGFR-β) and PDGFR-α/β receptor complexes, activating intracellular signaling pathways including PI3K/AKT, MAPK, and STAT, which regulate fibroblast activation, smooth muscle cell proliferation, and extracellular matrix production. In rabbits, PDGF-BB is produced by platelets, macrophages, endothelial cells, fibroblasts, and other stromal cells, and is released during tissue injury, inflammation, and wound healing. Rabbit PDGF-BB has been widely studied in models of vascular biology, atherosclerosis, and tissue repair, where PDGF signaling contributes to vascular smooth muscle cell proliferation, angiogenesis, and extracellular matrix remodeling. It also participates in dermal wound healing and fibrotic responses, influencing fibroblast migration and connective tissue regeneration following injury. Because rabbits are commonly used as experimental models for cardiovascular disease, wound healing, and regenerative medicine, characterization of rabbit PDGF-BB supports studies of growth factor signaling, vascular remodeling, and tissue regeneration relevant to both veterinary health and human biomedical research.