Cynomolgus Monkey (Macaca fascicularis) Platelet-Derived Growth Factor-BB (PDGF-BB) is a homodimeric growth factor composed of two PDGF-B chains that regulates cell proliferation, migration, angiogenesis, and tissue repair in nonhuman primates. PDGF-BB signals primarily through platelet-derived growth factor receptor-β (PDGFR-β) and PDGFR-α/β receptor complexes, activating downstream signaling pathways including PI3K/AKT, MAPK, and STAT, which control fibroblast activation, smooth muscle cell proliferation, and extracellular matrix production. In cynomolgus monkeys, PDGF-BB is produced by platelets, macrophages, endothelial cells, fibroblasts, and other stromal cells, and is released during tissue injury, inflammation, and wound healing. It contributes to vascular development, connective tissue remodeling, and repair of damaged tissues following injury. Because cynomolgus monkeys are widely used in preclinical biomedical research, PDGF-BB is studied in models of fibrosis, vascular disease, wound healing, and cancer, where PDGF signaling influences angiogenesis, stromal cell activation, and tissue remodeling. As a regulator of mesenchymal cell growth and vascular remodeling, cynomolgus monkey PDGF-BB provides an important translational model for studying growth factor signaling, regenerative processes, and therapeutic targeting of PDGF pathways relevant to human disease.