Mouse angiogenin (ANG) refers to members of the murine angiogenin family within the RNase A superfamily and plays important roles in angiogenesis, tissue remodeling, and cellular stress responses. Unlike humans, mice possess multiple angiogenin paralogs (e.g., Ang1–Ang4), which are expressed in a tissue-specific manner and contribute to endothelial cell proliferation, migration, and capillary formation through activation of pro-angiogenic signaling pathways and stimulation of ribosomal RNA transcription. In addition to its vascular functions, mouse angiogenin participates in regulation of cellular survival during hypoxic or inflammatory stress and has been implicated in host defense and gut mucosal biology, particularly Ang4, which is expressed in Paneth cells. Baseline expression in healthy mice varies by tissue but is generally low to moderate in circulation, with increased levels observed during wound healing, ischemia, tumor growth, inflammation, and experimental vascular injury. In biomedical research, mouse angiogenin is widely studied in models of cancer, atherosclerosis, myocardial infarction, peripheral vascular disease, inflammatory bowel disease, and neurodegeneration. Characterizing angiogenin expression in mice provides valuable insight into mechanisms of neovascularization, tissue regeneration, immune modulation, and angiogenesis-driven disease processes in experimental models.