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Mouse TIM-3 (HAVCR2) (Yeast-derived Recombinant Protein) - 500 micrograms

RP1470M-500
$3000.00
In Stock
Data SheetAdd to Cart

Bulk quantities of proteins are available. Please contact us for bulk pricing.

Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), was first described as a cell surface molecule expressed on IFNγ producing CD4+ Th1 and CD8+ Tc1 cells. Later, the expression was detected in Th17 cells, regulatory T-cells, and innate immune cells (dendritic cells, NK cells, monocytes). HAVCR2 expression is up regulated in tumor-infiltrating lymphocytes in lung, gastric, head and neck cancer, schwannoma, melanoma and follicular B-cell non-Hodgkin lymphoma. The TIM-3 pathway may interact with the PD-1 pathway in the dysfunctional CD8+ T cells and Tregs in cancer. HAVCR2 is mainly expressed on activated CD8+ T cells and suppresses macrophage activation following PD-1 inhibition. Upregulation was observed in tumors progressing after anti-PD-1 therapy. HAVCR2 is an immune checkpoint and together with other inhibitory receptors including programmed cell death protein 1 (PD-1) and lymphocyte activation gene 3 protein (LAG3) mediate the CD8+ T-cell exhaustion. HAVCR2 has also been shown as a CD4+ Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.

Alternate Names - HAVCR2, HAVcr-2, KIM-3, TIM3, TIMD-3, TIMD3, Tim-3, CD366, hepatitis A virus cellular receptor 2, SPTCL

Amino Acid Homology Across Species
Mus musculus (house mouse) TIM-3 – 100%
​More… https://blast.ncbi.nlm.nih.gov

Catalog No.:
RP1470M-500
Quantity:
500 ug
Source:
The Mouse TIM-3 recombinant protein was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
MW:
The mouse TIM-3 (HAVCR2) recombinant protein has a predicted molecular weight of 19.3 kDa
Protein Sequence:

RSLENAYVFE VGKNAYLPCS YTLSTPGALV PMCWGKGFCP WSQCTNELLR TDERNVTYQK SSRYQLKGDL NKGDVSLIIK NVTLDDHGTY CCRIQFPGLM NDKKLELKLD IKAAKVTPAQ TAHGDSTTAS PRTLTTERNG SETQTLVTLH NNNGTKISTW ADEIKDSGET IRTA (174)

Alias:
HAVCR2
Country of Origin:
USA
Applications:
The mouse TIM-3 (HAVCR2) endotoxin-free recombinant protein can be used in cell culture, as an TIM-3 ELISA Standard, and as a Western Blot Control.
None at this time

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