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Human CCL3 (MIP-1 alpha) Recombinant Protein
- Catalog Number:
- RP1481H
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Homo sapiens (human)
- Human CCL3 (MIP-1α, Macrophage Inflammatory Protein-1 alpha) (catalog RP1481H) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~7.8 kDa, 70 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to human. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CCL3/MIP-1α signaling and immune-cell chemotaxis (including recruitment and activation of monocytes, T cells, and other leukocytes during inflammatory responses); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | ASLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPGV IFLTKRSRQV CADPSEEWVQ KYVSDLELSA (70) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 7.8 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Human CCL3 (C-C motif chemokine ligand 3, also known as MIP-1α, macrophage inflammatory protein-1 alpha) is a pro-inflammatory chemokine that plays a central role in immune cell recruitment and activation during inflammatory and infectious responses. CCL3 primarily signals through the CCR1 and CCR5 receptors, promoting chemotaxis of monocytes, macrophages, dendritic cells, natural killer (NK) cells, and activated T lymphocytes to sites of infection, tissue injury, or immune activation. In humans, CCL3 is produced by activated macrophages, dendritic cells, T cells, epithelial cells, and endothelial cells in response to inflammatory stimuli such as microbial products and cytokines including TNF-α and IL-1β. CCL3 contributes to host defense by coordinating leukocyte trafficking and amplifying inflammatory signaling, but dysregulated or sustained expression is associated with chronic inflammatory and immune-mediated diseases, including rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, and psoriasis. CCL3 is also involved in viral infections such as HIV, where it can influence viral entry by competing for the CCR5 coreceptor, and in cancer, where it contributes to immune cell infiltration and tumor microenvironment remodeling. Because of its key role in immune cell migration and inflammatory signaling, human CCL3 is widely studied as both a biomarker of inflammation and a potential therapeutic target in infectious disease, autoimmune disorders, and cancer immunology.
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