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Human CCL2 (MCP-1) Recombinant Protein
- Catalog Number:
- RP1482H
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Gorilla gorilla gorilla (western lowland gorilla), Homo sapiens (human), Pan troglodytes (chimpanzee)
- Human CCL2 (MCP-1, Monocyte Chemoattractant Protein-1) (catalog RP1482H) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~8.9 kDa, 76 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with amino-acid homology to human, chimpanzee, and western lowland gorilla. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CCL2/MCP-1 signaling and immune-cell chemotaxis (including recruitment of monocytes, memory T cells, and dendritic cells to sites of inflammation); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | QPDAINAPVT CCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSMDHLDKQ TQTPKT (76) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 8.9 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Human CCL2 (C-C motif chemokine ligand 2, also known as monocyte chemoattractant protein-1, MCP-1) is a pro-inflammatory chemokine that plays a critical role in recruitment and activation of monocytes, macrophages, dendritic cells, and memory T cells during immune responses. CCL2 primarily signals through the CCR2 receptor, activating intracellular pathways that promote leukocyte migration, cytokine production, and coordination of innate and adaptive immunity at sites of infection, tissue injury, or inflammation. In humans, CCL2 is produced by a variety of cells including endothelial cells, fibroblasts, epithelial cells, and immune cells in response to inflammatory stimuli such as infection or tissue damage. While CCL2-mediated recruitment of monocytes is essential for host defense and tissue repair, dysregulated or excessive expression contributes to chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, and chronic kidney disease. CCL2 also plays an important role in cancer biology, where it promotes recruitment of tumor-associated macrophages that can support tumor growth, angiogenesis, and metastasis. As a key regulator of monocyte trafficking and inflammatory signaling, human CCL2 is widely studied as both a biomarker of inflammation and a therapeutic target in autoimmune disease, cardiovascular disease, cancer, and other chronic inflammatory conditions.
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