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Human CCL18 Recombinant Protein
- Catalog Number:
- RP1511H
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Homo sapiens (human)
- Human CCL18 (Pulmonary and Activation-Regulated Chemokine, PARC) (catalog RP1511H) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~7.9 kDa, 69 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to human. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CCL18/PARC signaling and immune-cell trafficking (including recruitment of lymphocytes and dendritic cells and roles in pulmonary inflammation and fibrosis); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | AQVGTNKELC CLVYTSWQIP QKFIVDYSET SPQCPKPGVI LLTKRGRQIC ADPNKKWVQK YISDLKLNA (69) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 7.9 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Human CCL18 (C-C motif chemokine ligand 18), also known as pulmonary and activation-regulated chemokine (PARC), is a member of the CC chemokine family that plays a significant role in immune regulation, particularly in Th2-associated and fibrotic conditions. CCL18 is produced predominantly by alternatively activated (M2) macrophages and dendritic cells, especially within the lungs and lymphoid tissues. It functions as a chemoattractant for naive T cells, B cells, and immature dendritic cells, and has been reported to interact with receptors including CCR8 and PITPNM3, contributing to immune cell recruitment and tissue remodeling. In healthy individuals, circulating CCL18 levels are detectable at low to moderate concentrations, but levels increase substantially in chronic inflammatory and fibrotic diseases. Elevated CCL18 has been strongly associated with pulmonary fibrosis, systemic sclerosis, atopic dermatitis, asthma, rheumatoid arthritis, and certain malignancies, where it may contribute to fibrosis, tumor progression, or maintenance of a Th2-biased microenvironment. In clinical and translational research, human CCL18 is widely studied as a biomarker of alternative macrophage activation and fibrosis and is considered a potential therapeutic target in chronic inflammatory and fibrotic disorders.
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