Turkey CCL3 (C-C motif chemokine ligand 3, also known as MIP-1α, macrophage inflammatory protein-1 alpha) is a pro-inflammatory chemokine involved in recruitment and activation of immune cells during inflammatory and infectious responses in turkeys (Meleagris gallopavo). CCL3 primarily signals through chemokine receptors homologous to mammalian CCR1 and CCR5, promoting chemotaxis of monocytes, macrophages, dendritic cells, natural killer–like cells, and activated T lymphocytes to sites of infection or tissue injury. In turkeys, CCL3 is produced by activated macrophages, epithelial cells, and lymphocytes in response to inflammatory stimuli such as pathogen-associated molecules and cytokines including IL-1β and TNF-like cytokines. CCL3-mediated immune cell recruitment plays an important role in host defense against pathogens associated with poultry respiratory and systemic diseases, including avian influenza virus, Newcastle disease virus, and bacterial infections such as Mycoplasma gallisepticum. While CCL3-driven leukocyte trafficking supports pathogen clearance and activation of immune responses, excessive or prolonged expression may contribute to inflammatory tissue damage. As a regulator of immune cell migration and inflammatory signaling, turkey CCL3 is important for studies of avian host–pathogen interactions, immune regulation, and vaccine responses, supporting research aimed at improving disease resistance and health in commercial poultry production.