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Feline CCL5 (RANTES) Recombinant Protein
- Catalog Number:
- RP1530F
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Felis catus (domestic cat)
- Feline CCL5 (RANTES, Regulated upon Activation, Normal T Cell Expressed and Secreted) (catalog RP1530F) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~7.9 kDa, 69 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to domestic cat. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CCL5/RANTES signaling and immune-cell chemotaxis (including recruitment of T cells, eosinophils, and basophils during inflammatory responses); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | SPYASDTTPC CFAYLSHPLP LTHLQEYFYT SSKCSMPAVV FVTRRKRQVC ANPQKKWVRD KGINSLEMN (69) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 7.9 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Feline CCL5 (C-C motif chemokine ligand 5, also known as RANTES - Regulated upon Activation, Normal T cell Expressed and Secreted) is a proinflammatory chemokine involved in immune cell recruitment and antiviral immune responses in cats (Felis catus). CCL5 is a member of the CC chemokine family, which includes related chemokines such as CCL3 (MIP-1α), CCL4 (MIP-1β), and CCL2 (MCP-1) that regulate leukocyte trafficking during immune activation. In cats, CCL5 is produced primarily by activated T lymphocytes, macrophages, dendritic cells, platelets, and epithelial cells in response to infection, inflammatory stimuli, or tissue injury. It exerts its biological effects mainly through binding to the chemokine receptors CCR1, CCR3, and CCR5, activating intracellular signaling pathways that promote chemotaxis and activation of T cells, monocytes, macrophages, eosinophils, and natural killer (NK) cells at sites of infection or inflammation. In feline health, CCL5 plays an important role in immune responses to viral infections such as feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV), as well as in inflammatory and immune-mediated diseases. Because CCL5 and its receptor CCR5 are involved in regulating antiviral immunity and leukocyte recruitment, feline CCL5 is studied in veterinary immunology, infectious disease research, and inflammatory disease models, helping to improve understanding of chemokine-mediated immune responses in cats.
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