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Human CCL7 Recombinant Protein
- Catalog Number:
- RP1531H
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Homo sapiens (human), Pan paniscus (pygmy chimpanzee), Pan troglodytes (chimpanzee)
- Human CCL7 (MCP-3, Monocyte Chemoattractant Protein-3) (catalog RP1531H) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~9.0 kDa, 76 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to human, pygmy chimpanzee, and chimpanzee. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CCL7/MCP-3 signaling and immune-cell chemotaxis (including recruitment of monocytes, eosinophils, basophils, and T lymphocytes during inflammatory responses); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | QPVGINTSTT CCYRFINKKI PKQRLESYRR TTSSHCPREA VIFKTKLDKE ICADPTQKWV QDFMKHLDKK TQTPKL (76) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 9.0 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Human CCL7 (C-C motif chemokine ligand 7, also known as MCP-3 - Monocyte Chemoattractant Protein-3) is a proinflammatory chemokine that plays an important role in leukocyte recruitment and regulation of inflammatory responses. CCL7 is a member of the CC chemokine family, which also includes CCL2 (MCP-1), CCL8 (MCP-2), and CCL13 (MCP-4), chemokines involved in monocyte and leukocyte trafficking during immune activation. In humans, CCL7 is produced by macrophages, fibroblasts, endothelial cells, epithelial cells, and tumor cells in response to infection, inflammatory cytokines, or tissue injury. CCL7 exerts its biological effects through interaction with multiple chemokine receptors, including CCR1, CCR2, CCR3, and CCR5, promoting chemotaxis and activation of monocytes, macrophages, dendritic cells, T lymphocytes, basophils, and eosinophils at sites of inflammation. Through these activities, CCL7 contributes to host defense against pathogens and coordination of innate and adaptive immune responses, but dysregulated expression has also been associated with chronic inflammatory diseases, cancer progression, and tumor-associated immune cell recruitment. Because of its role in immune cell trafficking and inflammatory signaling, human CCL7 is widely studied in immunology, infectious disease, cancer biology, and inflammatory disease research.
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