Human CCL7 (C–C motif chemokine ligand 7, also known as MCP-3 – Monocyte Chemoattractant Protein-3) is a proinflammatory chemokine that plays an important role in leukocyte recruitment and regulation of inflammatory responses. CCL7 is a member of the CC chemokine family, which also includes CCL2 (MCP-1), CCL8 (MCP-2), and CCL13 (MCP-4), chemokines involved in monocyte and leukocyte trafficking during immune activation. In humans, CCL7 is produced by macrophages, fibroblasts, endothelial cells, epithelial cells, and tumor cells in response to infection, inflammatory cytokines, or tissue injury. CCL7 exerts its biological effects through interaction with multiple chemokine receptors, including CCR1, CCR2, CCR3, and CCR5, promoting chemotaxis and activation of monocytes, macrophages, dendritic cells, T lymphocytes, basophils, and eosinophils at sites of inflammation. Through these activities, CCL7 contributes to host defense against pathogens and coordination of innate and adaptive immune responses, but dysregulated expression has also been associated with chronic inflammatory diseases, cancer progression, and tumor-associated immune cell recruitment. Because of its role in immune cell trafficking and inflammatory signaling, human CCL7 is widely studied in immunology, infectious disease, cancer biology, and inflammatory disease research.