Mouse Insulin-like Growth Factor 2 (IGF-2) is a peptide growth factor that plays an important role in regulating embryonic development, tissue growth, and metabolic processes in mice (Mus musculus). IGF-2 is expressed in multiple tissues, particularly during fetal and early postnatal development, where it promotes cell proliferation, differentiation, and survival. Mouse IGF-2 primarily binds to the insulin-like growth factor 1 receptor (IGF1R) and can also interact with the insulin receptor, activating intracellular signaling pathways including PI3K–AKT and MAPK that regulate gene expression, cell growth, and metabolism. In addition, IGF-2 interacts with the IGF-2 receptor (IGF2R), which functions mainly to regulate IGF-2 availability and signaling through ligand internalization and degradation. In mice, IGF-2 plays a critical role in placental function, fetal growth, and organ development, and it is essential for proper regulation of prenatal body size and tissue formation. Due to its important developmental roles and well-characterized genomic imprinting, mouse IGF-2 is widely studied in murine models of developmental biology, growth regulation, imprinting disorders, and cancer research.