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Bovine IGF-2 Recombinant Protein
- Catalog Number:
- RP1547B
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Bos grunniens (domestic yak), Bos indicus (zebu), Bos mutus (wild yak), Bos taurus (cattle), Bubalus bubalis (water buffalo)
- Bovine IGF-2 (Insulin-like Growth Factor 2) (catalog RP1547B) is a yeast-derived growth factor supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~7.5 kDa, 67 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to cattle, wild yak, zebu, domestic yak, and water buffalo. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IGF-2 signaling and cellular processes (including regulation of cell growth, proliferation, differentiation, and development); typical experimental uses include cell-culture stimulation and growth assays, signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | AYRPSETLCG GELVDTLQFV CGDRGFYFSR PSSRINRRSR GIVEECCFRS CDLALLETYC ATPAKSE (67) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 7.5 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Bovine Insulin-like Growth Factor 2 (IGF-2) is a peptide growth factor that plays an important role in regulating embryonic development, tissue growth, and metabolic processes in cattle (Bos taurus). IGF-2 is expressed in multiple tissues, particularly during fetal development, where it contributes to cell proliferation, differentiation, and survival. Bovine IGF-2 binds primarily to the insulin-like growth factor 1 receptor (IGF1R) and can also interact with the insulin receptor, activating intracellular signaling pathways including PI3K-AKT and MAPK that regulate gene expression, cell growth, and metabolism. In cattle, IGF-2 is especially important during prenatal growth, supporting placental function, fetal tissue development, and organ formation. Beyond development, IGF-2 may contribute to postnatal tissue maintenance and metabolic regulation. Due to its roles in growth and development, bovine IGF-2 is widely studied in livestock biology, reproductive physiology, and agricultural research, where it is associated with fetal growth, muscle development, and traits relevant to cattle production and health.
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