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Feline CCL2 (MCP-1) Recombinant Protein
- Catalog Number:
- RP1548F
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Acinonyx jubatus (cheetah), Felis catus (domestic cat), Puma concolor (puma)
- Feline CCL2 (MCP-1, Monocyte Chemoattractant Protein-1) (catalog RP1548F) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~8.6 kDa, 76 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to domestic cat, puma, and cheetah. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CCL2/MCP-1 signaling and immune-cell chemotaxis (including recruitment of monocytes and other leukocytes during inflammatory responses); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | QPDAINSPVT CCYTLTNKKI SMQRLVSYKR VTSSKCPKEA VIFKTILNKE ICADPNQKWV KDSMAHLDKK TQTAKP (76) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 8.6 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Feline CCL2 (C-C motif chemokine ligand 2, also known as monocyte chemoattractant protein-1, MCP-1) is a pro-inflammatory chemokine that plays a key role in recruitment and activation of monocytes, macrophages, and memory T cells during immune responses in cats (Felis catus). CCL2 signals primarily through the CCR2 receptor, activating downstream pathways that promote leukocyte migration, cytokine production, and coordination of innate and adaptive immune responses at sites of infection or tissue injury. In feline health, CCL2 is particularly relevant in inflammatory and infectious diseases such as feline infectious peritonitis (FIP) caused by feline coronavirus, feline immunodeficiency virus (FIV) infection, chronic kidney disease, and inflammatory bowel disease, where elevated CCL2 expression contributes to macrophage recruitment and local inflammatory pathology. While CCL2-mediated immune cell trafficking is essential for pathogen defense and tissue repair, dysregulated or excessive expression can drive chronic inflammation and immune-mediated tissue damage. As a biomarker of monocyte/macrophage recruitment and inflammatory activation, feline CCL2 is widely studied in investigations of host-pathogen interactions, immune regulation, and disease pathogenesis. Characterization of feline CCL2 supports veterinary research into inflammatory disease mechanisms and provides comparative insight into chemokine-driven immune responses relevant to human infectious and inflammatory disorders.
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