Zebrafish (Danio rerio) CCL2 (C-C motif chemokine ligand 2, also referred to as an MCP-1–like chemokine) is a pro-inflammatory chemokine involved in recruitment and activation of monocytes/macrophages and other leukocytes during innate immune responses. Similar to its mammalian counterpart, zebrafish CCL2-like signaling promotes leukocyte migration to sites of infection, tissue injury, or inflammation through chemokine receptor pathways functionally related to CCR2, coordinating early immune responses and inflammatory cytokine production. In zebrafish, CCL2 expression is induced during bacterial infections (e.g., Mycobacterium marinum), viral challenges, and tissue damage, where macrophage recruitment is essential for pathogen containment, granuloma formation, and tissue repair. Zebrafish models have been widely used to visualize chemokine-driven immune cell migration in vivo using fluorescent reporter lines and live imaging, allowing detailed study of macrophage dynamics and inflammatory signaling. While CCL2-mediated leukocyte recruitment supports host defense and wound healing, excessive or sustained expression can contribute to chronic inflammation or tissue pathology. Because zebrafish are a powerful vertebrate model for innate immunity, infection biology, and inflammatory disease, characterization of zebrafish CCL2-like chemokine signaling provides important insight into the evolution of chemokine networks and mechanisms of immune cell trafficking relevant to human inflammatory and infectious diseases.