Slide 1 of 1 
Feline Amphiregulin Recombinant Protein
- Catalog Number:
- RP1580F
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Felis catus (domestic cat), Lynx canadensis (Canada lynx)
- Feline Amphiregulin (AR) (catalog RP1580F) is a yeast-derived growth factor supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~10.0 kDa, 87 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with amino-acid homology to domestic cat and Canada lynx. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study amphiregulin/EGFR signaling and cellular processes (including regulation of cell proliferation, differentiation, and tissue repair); typical experimental uses include cell-culture stimulation and growth assays, signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMKTHS MIDSSLSK (98) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 10.0 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Feline amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family and functions as a ligand for the epidermal growth factor receptor (EGFR/ErbB1), where it regulates epithelial cell proliferation, differentiation, tissue repair, and inflammatory responses. In cats (Felis catus), amphiregulin is produced by epithelial cells, fibroblasts, keratinocytes, and activated immune cells including T lymphocytes and mast cells, particularly in response to tissue injury, allergen exposure, and inflammatory cytokines. Through activation of EGFR signaling pathways, amphiregulin contributes to wound healing, mucosal barrier maintenance, and remodeling of epithelial tissues, but dysregulated expression may also promote chronic inflammation, fibrosis, or tumor progression. In veterinary and comparative medicine research, feline amphiregulin is of interest in studies of allergic skin disease (e.g., atopic dermatitis), asthma, inflammatory bowel disease, wound repair, and neoplastic conditions such as squamous cell carcinoma and mammary carcinoma, where EGFR-driven signaling plays a role. Understanding amphiregulin expression and function in cats provides insight into epithelial-immune crosstalk, tissue remodeling processes, and potential therapeutic targets in both veterinary and translational oncology and inflammatory disease research.
Please choose a size to see price
RELATED MEDIA
