Rabbit amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family and functions as a ligand for the epidermal growth factor receptor (EGFR/ErbB1), where it regulates epithelial cell proliferation, differentiation, survival, and tissue repair. In rabbits (Oryctolagus cuniculus), amphiregulin is produced by epithelial cells, keratinocytes, fibroblasts, and activated immune cells in response to tissue injury, inflammatory cytokines, and immune stimulation. Through activation of EGFR-dependent signaling pathways such as MAPK and PI3K/AKT, rabbit amphiregulin contributes to wound healing, mucosal barrier maintenance, and tissue remodeling, particularly in skin, respiratory, and gastrointestinal tissues. Dysregulated expression may be associated with chronic inflammation, fibrosis, or tumor development. In biomedical and translational research, rabbit amphiregulin is of interest in models of cutaneous wound repair, airway inflammation, gastrointestinal injury, ocular surface disease, and oncology studies where EGFR signaling plays a key role. Characterizing amphiregulin expression in rabbits provides valuable insight into epithelial–immune interactions, regenerative responses, and EGFR-driven pathophysiology in experimental models.