Swine amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family and functions as a ligand for the epidermal growth factor receptor (EGFR/ErbB1), where it regulates epithelial cell proliferation, differentiation, survival, and tissue repair. In pigs (Sus scrofa), amphiregulin is produced by epithelial cells, fibroblasts, keratinocytes, and activated immune cells—including Th2 cells and regulatory T cells—in response to tissue injury, inflammatory cytokines, and microbial stimulation. Through activation of EGFR-dependent signaling pathways such as MAPK and PI3K/AKT, swine amphiregulin contributes to mucosal barrier integrity, wound healing, and tissue remodeling in respiratory, gastrointestinal, and cutaneous tissues. Dysregulated amphiregulin expression may be associated with chronic inflammation, fibrosis, or tumorigenesis. In veterinary and translational research, swine amphiregulin is of particular interest in porcine models of respiratory disease (e.g., PRRSV and swine influenza), inflammatory bowel disease–like conditions, wound healing and regenerative medicine studies, and oncology research, given the physiological similarities between pigs and humans. Characterizing amphiregulin expression in swine provides valuable insight into epithelial–immune crosstalk, EGFR-mediated signaling, and tissue repair mechanisms in both agricultural and biomedical research settings.