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Swine Amphiregulin Recombinant Protein
- Catalog Number:
- RP1608S
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Sus scrofa (pig)
- Swine Amphiregulin (AR) (catalog RP1608S) is a yeast-derived growth factor supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~10.2 kDa, 87 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with amino-acid homology to pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study amphiregulin/EGFR signaling and cellular processes (including regulation of cell proliferation, differentiation, and tissue repair); typical experimental uses include cell-culture stimulation and growth assays, signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | SVRVEQVVKP KRNRTESENT SDKPKRKKKG GKSGKNRRNR KKKNPCDAEF QNFCIHGDCK YIEHLEAVTC KCYQDYFGER CGEKSMK (87) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 10.2 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Swine amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family and functions as a ligand for the epidermal growth factor receptor (EGFR/ErbB1), where it regulates epithelial cell proliferation, differentiation, survival, and tissue repair. In pigs (Sus scrofa), amphiregulin is produced by epithelial cells, fibroblasts, keratinocytes, and activated immune cells-including Th2 cells and regulatory T cells-in response to tissue injury, inflammatory cytokines, and microbial stimulation. Through activation of EGFR-dependent signaling pathways such as MAPK and PI3K/AKT, swine amphiregulin contributes to mucosal barrier integrity, wound healing, and tissue remodeling in respiratory, gastrointestinal, and cutaneous tissues. Dysregulated amphiregulin expression may be associated with chronic inflammation, fibrosis, or tumorigenesis. In veterinary and translational research, swine amphiregulin is of particular interest in porcine models of respiratory disease (e.g., PRRSV and swine influenza), inflammatory bowel disease-like conditions, wound healing and regenerative medicine studies, and oncology research, given the physiological similarities between pigs and humans. Characterizing amphiregulin expression in swine provides valuable insight into epithelial-immune crosstalk, EGFR-mediated signaling, and tissue repair mechanisms in both agricultural and biomedical research settings.
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