Ferret CCL5 (C–C motif chemokine ligand 5, also known as RANTES – Regulated upon Activation, Normal T cell Expressed and Secreted) is a proinflammatory chemokine that regulates immune cell recruitment and inflammatory responses in ferrets (Mustela putorius furo). CCL5 is a member of the CC chemokine family, which also includes CCL3 (MIP-1α), CCL4 (MIP-1β), and CCL2 (MCP-1), chemokines that coordinate leukocyte trafficking during immune activation. In ferrets, CCL5 is produced primarily by activated T lymphocytes, macrophages, dendritic cells, platelets, and epithelial cells in response to viral infection, inflammatory stimuli, or tissue injury, and it exerts its biological effects mainly through binding to the chemokine receptors CCR1, CCR3, and CCR5, promoting chemotaxis and activation of T cells, monocytes/macrophages, eosinophils, and natural killer (NK) cells at sites of infection or inflammation. Ferrets are widely used as animal models for respiratory viral diseases, including influenza and SARS-related coronaviruses, and chemokines such as CCL5 play an important role in recruiting immune cells to the respiratory tract during viral infection, contributing to both antiviral defense and inflammatory pathology. Consequently, ferret CCL5 is frequently studied in infectious disease, immunology, and vaccine research, helping to elucidate mechanisms of chemokine-mediated immune responses and inflammatory regulation in respiratory disease models.