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Human IFN alpha Recombinant Protein
- Catalog Number:
- RP1628H
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Gorilla gorilla gorilla (western lowland gorilla), Homo sapiens (human)
- Human IFN-α (Interferon alpha) (catalog RP1628H) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~19.4 kDa, 166 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to human and western lowland gorilla. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IFN-α signaling and antiviral immune responses (including regulation of innate immunity, antiviral defense, and immune modulation); typical experimental uses include cell-culture stimulation and antiviral assays, cytokine signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | CDLPETHSLD NRRTLMLLAQ MSRISPSSCL MDRHDFGFPQ EEFDGNQFQK APAISVLHEL IQQIFNLFTT KDSSAAWDED LLDKFCTELY QQLNDLEACV MQEERVGETP LMNADSILAV KKYFRRITLY LTEKKYSPCA WEVVRAEIMR SLSLSTNLQE RLRRKE (166) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 19.4 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Human Interferon-Alpha (IFN-α) is a type I interferon family consisting of multiple closely related subtypes (e.g., IFN-α1, IFN-α2, IFN-α8, IFN-α14, among others) produced primarily by plasmacytoid dendritic cells and virus-infected cells, where it plays a central role in early innate antiviral immunity. Upon binding to the type I interferon receptor complex (IFNAR1/IFNAR2), IFN-α activates the JAK/STAT signaling pathway, leading to induction of hundreds of interferon-stimulated genes (ISGs) that inhibit viral replication, enhance antigen presentation, promote natural killer (NK) cell cytotoxicity, and shape adaptive immune responses. Human IFN-α is critical in defense against viral infections such as influenza, hepatitis B and C viruses, HIV, SARS-CoV-2, and other emerging pathogens, and impaired or delayed IFN-α responses are associated with severe viral disease. Conversely, excessive or chronic IFN-α production contributes to autoimmune and inflammatory disorders including systemic lupus erythematosus (SLE), type I interferonopathies, and certain dermatologic conditions. Clinically, recombinant IFN-α has been used as a therapeutic agent in chronic viral hepatitis and specific malignancies such as hairy cell leukemia and melanoma. As both a biomarker and therapeutic target, human IFN-α is central to research on antiviral immunity, immune dysregulation, cancer immunotherapy, and development of interferon-modulating treatments.
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