Rabbit Midkine (MK) is a heparin-binding growth factor and cytokine that plays important roles in cell growth, development, and tissue repair in rabbits (Oryctolagus cuniculus). Midkine is highly expressed during embryonic development and can also be induced in adult tissues in response to injury, inflammation, or physiological stress. Rabbit midkine interacts with several cell surface receptors, including receptor-type protein tyrosine phosphatase ζ (PTPRZ1), low-density lipoprotein receptor–related proteins (LRPs), and integrins, activating intracellular signaling pathways such as MAPK, PI3K–AKT, and NF-κB that regulate cell proliferation, migration, survival, and inflammatory responses. Through these mechanisms, midkine contributes to processes including neural development, angiogenesis, immune cell recruitment, and tissue regeneration. In cell culture, recombinant rabbit midkine is commonly used to stimulate cell proliferation and migration and to study growth factor–mediated signaling pathways involved in development, inflammation, and tissue repair. Rabbit midkine is also studied in rabbit animal models of cardiovascular disease, atherosclerosis, and tissue injury, where it helps researchers investigate mechanisms of inflammation, vascular remodeling, and regenerative responses.