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Bovine TGF-alpha Recombinant Protein
- Catalog Number:
- RP1634B
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Bison bison bison (American buffalo), Bos indicus (zebu), Bos mutus (wild yak), Bos taurus (cattle), Bubalus bubalis (water buffalo)
- Bovine TGF-α (Transforming Growth Factor alpha) (catalog RP1634B) is a yeast-derived growth factor supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~5.5 kDa, 50 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to cattle, American buffalo, zebu, wild yak, and water buffalo. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study TGF-α/EGFR signaling and cellular processes (including regulation of cell proliferation, differentiation, and tissue development); typical experimental uses include cell-culture stimulation and growth assays, signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | VVSHFNDCPD SHSQFCFHGT CRFLVQEEKP ACVCHSGYVG ARCEHADLLA (50) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 5.5 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Bovine Transforming Growth Factor Alpha (TGF-α) is a member of the epidermal growth factor (EGF) family of growth factors, which also includes epidermal growth factor (EGF), amphiregulin, betacellulin, epiregulin, and heparin-binding EGF-like growth factor (HB-EGF). In cattle (Bos taurus), TGF-α is synthesized as a membrane-bound precursor protein that is proteolytically cleaved to release a soluble ligand capable of binding the epidermal growth factor receptor (EGFR/ErbB1). Activation of EGFR by TGF-α triggers intracellular signaling pathways including MAPK/ERK, PI3K/AKT, and JAK/STAT, which regulate cell proliferation, differentiation, migration, and tissue development. Bovine TGF-α is expressed in multiple tissues such as the mammary gland, skin, gastrointestinal tract, and reproductive tissues, where it contributes to epithelial cell growth, tissue regeneration, and organ development. In cattle, TGF-α signaling is particularly relevant in mammary gland development and epithelial turnover, processes that influence lactation physiology and mammary tissue remodeling. It also participates in wound healing and tissue repair following injury. Because TGF-α regulates epithelial growth and EGFR signaling, bovine TGF-α is studied in research on mammary gland biology, tissue regeneration, growth factor signaling, and epithelial cell proliferation relevant to cattle health and dairy productivity.
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