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Human IL-31 Recombinant Protein
- Catalog Number:
- RP1639H
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Homo sapiens (human)
- Human IL-31 (Interleukin-31) (catalog RP1639H) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~15.8 kDa, 141 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to human. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-31 signaling and immune responses (including roles in inflammation, pruritus, and regulation of cytokine networks); typical experimental uses include cell-culture stimulation and cytokine assays, signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T (141) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 15.8 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Human Interleukin-31 (IL-31) is a cytokine involved in the regulation of immune responses and inflammatory signaling in humans (Homo sapiens). IL-31 is produced primarily by activated T helper 2 (Th2) cells, as well as by other immune cells such as mast cells and macrophages following immune stimulation. Human IL-31 binds to a heterodimeric receptor complex composed of IL-31 receptor A (IL-31RA) and oncostatin M receptor (OSMR), activating intracellular signaling pathways including JAK-STAT, MAPK, and PI3K that regulate gene expression, inflammation, and cellular responses. Through these signaling pathways, IL-31 contributes to communication between immune cells and epithelial tissues and plays a key role in regulating inflammatory processes, particularly in the skin and mucosal tissues. In humans, IL-31 has been strongly associated with pruritus (itch) and inflammatory skin diseases such as atopic dermatitis and chronic pruritic disorders. Due to its involvement in allergic inflammation and itch signaling, human IL-31 is widely studied in immunology and translational biomedical research, including investigations of allergic disease mechanisms and development of targeted therapies for inflammatory skin conditions.
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