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Bovine CCL19 (MIP-3 beta) Recombinant Protein
- Catalog Number:
- RP1651B
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Bison bison bison (American buffalo), Bos indicus (zebu), Bos mutus (wild yak), Bos taurus (cattle), Bubalus bubalis (water buffalo)
- Bovine CCL19 (MIP-3β, Macrophage Inflammatory Protein-3 beta) (catalog RP1651B) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~8.9 kDa, 79 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to cattle, American buffalo, zebu, wild yak, and water buffalo. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CCL19/MIP-3β signaling and immune-cell trafficking (including regulation of lymphocyte migration and homing to lymphoid tissues); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | GANDAEDCCL SVTQRPIPVF LVRAYRYLLL KDGCRLPAVV FTTQRGHELC APPDQPWVGR IIRRLKKNSA RRSVPAVTL (79) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 8.9 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Bovine CCL19 (C-C motif chemokine ligand 19), also known as macrophage inflammatory protein-3β (MIP-3β) or EBI1 ligand chemokine (ELC), is a member of the CC chemokine family that plays a central role in lymphocyte trafficking and organization of secondary lymphoid tissues in cattle (Bos taurus). CCL19 is primarily produced by stromal cells, dendritic cells, and macrophages within lymph nodes, spleen, and other lymphoid structures. It functions through the CCR7 receptor to direct migration of naive T cells, central memory T cells, and mature dendritic cells to lymphoid tissues, facilitating antigen presentation and initiation of adaptive immune responses. In healthy cattle, CCL19 contributes to immune surveillance and maintenance of lymphoid architecture; however, expression may increase during infection, vaccination, or inflammatory stimulation. In veterinary and agricultural research, bovine CCL19 is of particular interest in studies of vaccine-induced immunity, lymphoid tissue organization, and host responses to pathogens such as bovine respiratory disease complex agents, bovine viral diarrhea virus (BVDV), and Mycobacterium avium subspecies paratuberculosis (Johne's disease). Characterization of CCL19 in cattle provides valuable insight into CCR7-mediated immune cell trafficking and adaptive immune regulation in livestock health and disease.
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