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Guinea Pig M-CSF Recombinant Protein
- Catalog Number:
- RP1655GP
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Cavia porcellus (Domestic guinea pig)
- Guinea Pig M-CSF (Macrophage Colony-Stimulating Factor, CSF-1) (catalog RP1655GP) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~26.1 kDa, 230 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to domestic guinea pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study M-CSF signaling and hematopoiesis (including regulation of macrophage differentiation, proliferation, and survival); typical experimental uses include cell-culture stimulation and differentiation assays, cytokine signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | EEISEHCSHM IGNGHLQALQ HLIDSQMETS CHITFEFADE EQLKDPVCYL KKAFLLVDDI MEDTMRFRDE TPNAKAIIQL QTLSVRLKSC FTKDYEKQDK ACVRTFYETP LQLMEKIKNV FNETKNLLEE DWKIFTKNCS DSFAKCSSPD VVTKPDCNCL YPKATPSSDL ASVSPHQPFI PSKVPKTGLT WADSEGTEGR SLLPNKQLLH TVDPGTAKHR PPRSTCQSLE (230) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 26.1 kda |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Guinea Pig Macrophage Colony-Stimulating Factor (M-CSF) is a cytokine that regulates the development, proliferation, and survival of monocytes and macrophages in guinea pigs (Cavia porcellus). M-CSF is produced by several cell types, including fibroblasts, endothelial cells, epithelial cells, and stromal cells, in response to tissue signals and inflammatory stimuli. Guinea pig M-CSF binds to the colony-stimulating factor-1 receptor (CSF1R), a receptor tyrosine kinase expressed on monocytes and macrophage lineage cells, activating intracellular signaling pathways such as PI3K-AKT, ERK/MAPK, and JAK-STAT that promote differentiation and maintenance of macrophage populations. Through these mechanisms, M-CSF supports macrophage-mediated immune surveillance, phagocytosis, tissue homeostasis, and inflammatory responses. Because macrophages play a key role in host defense, M-CSF-mediated macrophage function is important for maintaining immune health and resistance to infection in guinea pigs. In cell culture, recombinant guinea pig M-CSF is commonly used to promote differentiation of guinea pig monocytes into macrophages and to support macrophage proliferation and functional assays in vitro. Guinea pig M-CSF is also studied in animal model research, particularly in guinea pig models of infectious diseases such as tuberculosis, where macrophage responses are critical for understanding host-pathogen interactions and immune defense mechanisms.
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