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Guinea Pig TGF-alpha Recombinant Protein
- Catalog Number:
- RP1657GP
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Cavia porcellus (Domestic guinea pig), Chinchilla lanigera (long-tailed chinchilla)
- Guinea Pig TGF-α (Transforming Growth Factor alpha) (catalog RP1657GP) is a yeast-derived growth factor supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~5.6 kDa, 50 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to domestic guinea pig and long-tailed chinchilla. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study TGF-α/EGFR signaling and cellular processes (including regulation of cell proliferation, differentiation, and tissue development); typical experimental uses include cell-culture stimulation and growth assays, signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | VLSHFNDCPD SHTQFCFHGT CRFLVQEDKP ACVCHSGYVG ARCEHADLLA (50) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 5.6 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Guinea Pig Transforming Growth Factor Alpha (TGF-α) is a member of the epidermal growth factor (EGF) family of growth factors, which includes epidermal growth factor (EGF), amphiregulin, betacellulin, epiregulin, and heparin-binding EGF-like growth factor (HB-EGF). In guinea pigs (Cavia porcellus), TGF-α is synthesized as a membrane-bound precursor protein (pro-TGF-α) that is cleaved to release a soluble ligand capable of binding the epidermal growth factor receptor (EGFR/ErbB1). Activation of EGFR triggers intracellular signaling pathways such as MAPK/ERK, PI3K/AKT, and JAK/STAT, which regulate cell proliferation, differentiation, epithelial growth, and tissue repair. Guinea pig TGF-α is expressed in multiple tissues including the skin, gastrointestinal tract, respiratory epithelium, and reproductive tissues, where it contributes to epithelial cell turnover, tissue regeneration, and developmental processes. In guinea pigs, TGF-α signaling is also relevant in wound healing and inflammatory responses, where EGFR-mediated signaling promotes epithelial repair and cellular migration. Because guinea pigs are widely used as experimental models for dermatology, respiratory biology, and developmental studies, characterization of guinea pig TGF-α supports research on EGFR signaling, epithelial biology, and growth factor-mediated tissue regeneration relevant to both veterinary and comparative biomedical research.
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