Guinea Pig Transforming Growth Factor Alpha (TGF-α) is a member of the epidermal growth factor (EGF) family of growth factors, which includes epidermal growth factor (EGF), amphiregulin, betacellulin, epiregulin, and heparin-binding EGF-like growth factor (HB-EGF). In guinea pigs (Cavia porcellus), TGF-α is synthesized as a membrane-bound precursor protein (pro–TGF-α) that is cleaved to release a soluble ligand capable of binding the epidermal growth factor receptor (EGFR/ErbB1). Activation of EGFR triggers intracellular signaling pathways such as MAPK/ERK, PI3K/AKT, and JAK/STAT, which regulate cell proliferation, differentiation, epithelial growth, and tissue repair. Guinea pig TGF-α is expressed in multiple tissues including the skin, gastrointestinal tract, respiratory epithelium, and reproductive tissues, where it contributes to epithelial cell turnover, tissue regeneration, and developmental processes. In guinea pigs, TGF-α signaling is also relevant in wound healing and inflammatory responses, where EGFR-mediated signaling promotes epithelial repair and cellular migration. Because guinea pigs are widely used as experimental models for dermatology, respiratory biology, and developmental studies, characterization of guinea pig TGF-α supports research on EGFR signaling, epithelial biology, and growth factor–mediated tissue regeneration relevant to both veterinary and comparative biomedical research.