Mouse Interleukin-16 (IL-16) is a proinflammatory cytokine that plays an important role in regulating immune cell recruitment and activation in mice (Mus musculus). IL-16 is produced by several cell types, including CD8⁺ T cells, mast cells, eosinophils, dendritic cells, and epithelial cells, in response to immune stimulation or inflammatory signals. Mouse IL-16 functions primarily as a chemoattractant for CD4⁺ immune cells by binding to the CD4 receptor, promoting migration and activation of T helper cells, monocytes, and dendritic cells to sites of infection or inflammation. Through these actions, IL-16 contributes to coordination of immune responses and modulation of inflammatory signaling pathways. In mice, IL-16 participates in immune responses against bacterial, viral, and parasitic pathogens and has been implicated in inflammatory and immune-mediated conditions. In cell culture, recombinant mouse IL-16 is used to study chemotaxis and activation of CD4⁺ immune cells, investigate mechanisms of immune cell recruitment, and evaluate cytokine-mediated regulation of inflammatory pathways. Mouse IL-16 is widely studied in murine models of inflammatory diseases such as asthma, autoimmune disorders, and infection, where it helps researchers examine immune cell trafficking and inflammatory signaling relevant to both basic immunology and translational biomedical research.