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Human CXCL3 Recombinant Protein
- Catalog Number:
- RP1673H
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Homo sapiens (human)
- Human CXCL3 (GRO-γ, Growth-Regulated Protein gamma) (catalog RP1673H) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~7.9 kDa, 73 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to human. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CXCL3/GRO-γ signaling and immune-cell chemotaxis (including recruitment and activation of neutrophils during inflammatory responses); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | ASVVTELRCQ CLQTLQGIHL KNIQSVNVRS PGPHCAQTEV IATLKNGKKA CLNPASPMVQ KIIEKILNKG STN (73) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 7.9 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Human CXCL3 (C-X-C motif chemokine ligand 3), also known as GRO-γ (growth-regulated oncogene gamma), is a proinflammatory chemokine belonging to the CXC chemokine family, which also includes CXCL1 (GRO-α) and CXCL2 (GRO-β) that regulate neutrophil recruitment during inflammatory responses. In humans (Homo sapiens), CXCL3 is produced by macrophages, monocytes, epithelial cells, endothelial cells, and fibroblasts in response to proinflammatory cytokines such as IL-1β and TNF-α, microbial products, or tissue injury. CXCL3 primarily signals through the chemokine receptor CXCR2, expressed on neutrophils and other innate immune cells, promoting chemotaxis, activation, and migration of neutrophils to sites of infection or inflammation. Through these actions, CXCL3 plays an important role in innate immune defense against bacterial infections and regulation of acute inflammatory responses, particularly in tissues such as the lung, skin, and gastrointestinal tract. Dysregulated CXCL3 expression has been implicated in chronic inflammatory diseases and cancer, where CXCL3-driven recruitment of neutrophils and other immune cells can influence tumor-associated inflammation, angiogenesis, and tumor progression. Consequently, human CXCL3 is widely studied in immunology, inflammatory disease research, and cancer biology as both a mediator of neutrophil trafficking and a potential therapeutic target for inflammatory and tumor-related conditions.
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