Anole Insulin-like Growth Factor 1 (IGF-1) is a peptide growth factor that plays a key role in regulating growth, development, and metabolic processes in anole lizards, such as the green anole (Anolis carolinensis). IGF-1 is produced primarily in the liver in response to growth hormone stimulation and is also expressed locally in various tissues including muscle, bone, and skin. Anole IGF-1 binds to the insulin-like growth factor 1 receptor (IGF1R), a transmembrane tyrosine kinase receptor, activating intracellular signaling pathways such as the PI3K–AKT and MAPK pathways that regulate cell proliferation, differentiation, and survival. In anoles, IGF-1 contributes to somatic growth, tissue maintenance, and metabolic regulation, and it plays an important role in processes such as skeletal development and muscle growth. Anole IGF-1 is also studied in reptile biology and evolutionary developmental research, where it serves as a key molecular regulator of growth and regeneration-related pathways in reptilian models.