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Swine IL-25 (IL-17E) Recombinant Protein
- Catalog Number:
- RP1678S
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Sus scrofa (pig)
- Swine IL-25 (IL-17E) (catalog RP1678S) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~17.1 kDa, 150 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-25/IL-17E signaling and immune responses (including regulation of type 2 immunity, inflammation, and cytokine production); typical experimental uses include cell-culture stimulation and cytokine assays, signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | WSQKGCPHWP NCCPSKGQNP IEEWLKQNAV LMPPLEMASP TPHPESCKAS EDGPLNSRSI APWRYELDRD LNRLPQDLYH ARCLCPHCVS LRTGSHMDPL GNSELLYHNQ TVFYRRPCPG QQGAHDSYCL EPRLYQVSLA CVCVRPRVMA (150) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 17.1 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Swine interleukin-25 (IL-25), also known as IL-17E, is a member of the IL-17 cytokine family and functions as a regulator of type 2 immune responses through signaling via the IL-17RA/IL-17RB receptor complex, activating downstream NF-κB and MAPK pathways. In swine, IL-25 is expected to promote Th2-associated cytokine production-including IL-4, IL-5, and IL-13-supporting eosinophil recruitment, mucosal immunity, and defense against helminths and other extracellular parasites that impact herd health. In porcine health, pIL-25 likely plays a role in gastrointestinal immunity, respiratory inflammation, and barrier protection, with relevance to conditions such as parasitic enteritis, post-weaning intestinal inflammation, and components of the porcine respiratory disease complex where immune balance is critical. While beneficial in anti-parasitic responses, excessive or dysregulated IL-25 signaling may contribute to allergic-type inflammation or reduced growth performance due to chronic immune activation. Given the physiological similarities between pigs and humans, particularly in pulmonary and gastrointestinal systems, porcine IL-25 is valuable not only for improving livestock health and vaccine strategies but also as a translational large-animal model for studying type 2-driven inflammatory diseases such as asthma and allergic gastrointestinal disorders.
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