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Feline M-CSF Recombinant Protein
- Catalog Number:
- RP1702F
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Felis catus (domestic cat), Lynx canadensis (Canada lynx), Lynx pardinus (Spanish lynx), Puma concolor (puma)
- Feline M-CSF (Macrophage Colony-Stimulating Factor, CSF-1) (catalog RP1702F) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~18.4 kDa, 158 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to domestic cat, Spanish lynx, Canada lynx, and puma. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study M-CSF signaling and hematopoiesis (including regulation of macrophage differentiation, proliferation, and survival); typical experimental uses include cell-culture stimulation and differentiation assays, cytokine signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | EEVSERCSHM IGNGHLQFLQ QLIDSQMETS CQIAFEFVDQ EQLKDPVCYL KKAFLLVQDI MEDTMRFKDN TPNANVIVTL QELSLRLSSC FTKDYEEQDK ACVRTFHETP LQLLEKIKNV FNETKNLLKK DWNVFSKNCN KSFEKCSSQG HDRQQEGP (158) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 18.4 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Feline Macrophage Colony-Stimulating Factor (M-CSF) is a cytokine that regulates the development, proliferation, and survival of monocytes and macrophages in cats (Felis catus). M-CSF is produced by a variety of cell types, including fibroblasts, endothelial cells, and stromal cells, in response to tissue signals and inflammatory stimuli. Feline M-CSF binds to the colony-stimulating factor-1 receptor (CSF1R), a receptor tyrosine kinase expressed on monocytes and macrophage lineage cells, activating intracellular signaling pathways such as PI3K-AKT, ERK/MAPK, and JAK-STAT that promote differentiation and maintenance of macrophage populations. Through these mechanisms, M-CSF supports macrophage-mediated immune surveillance, phagocytosis, tissue homeostasis, and inflammatory responses. Because macrophages play a central role in controlling infection and regulating inflammation, M-CSF-mediated macrophage function is important for maintaining overall immune health and disease resistance in cats. In cell culture, recombinant feline M-CSF is commonly used to promote differentiation of feline monocytes into macrophages and to support macrophage proliferation and functional assays in vitro. Feline M-CSF is also studied in animal model research, including investigations of macrophage responses during feline infectious diseases such as feline immunodeficiency virus (FIV) and feline infectious peritonitis (FIP), helping researchers better understand macrophage biology and host-pathogen interactions.
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